New Discovery Resets 75-Year-Old Skin to 30-Year-Old’s

Can engineered enzymes reverse "irreversible" protein aging? Researchers from Revel Pharmaceuticals, Calico Life Sciences, and the University of Colorado have developed CMLase; a bacterial enzyme variant capable of clearing up to 70% of advanced glycation end products (AGEs) in human tissue. Learn how oxidative deglycation breaks down toxic CML modifications, restores youthful protein profiles, and what this means for the future of longevity medicine. Some links are affiliate links so we will earn a commission when they are used to purchase products. 🧬 SUPPORT THE CHANNEL & LONGEVITY PARTNERS If you would like to support our channel please consider joining our Patreon https://patreon.com/ModernHealthspan ~~~~~~~~~~~~~~ *Renue By Science* (10% off: MHS) https://tinyurl.com/bdew4bfs NMN Powder • Lipo NR *BiOptimizers* (15% off: MHBIO) https://bit.ly/47VAa8f - Magnesium Breakthrough, Gluten Guardian *Seeking Health* (10% off: Richard10) https://crrnt.app/SEEK/-dm0MyrQ, Histamine Nutrients https://crrnt.app/SEEK/EpM7paAO *Stemregen* (15% off: MODERN) *US only* https://tinyurl.com/45z968yr Time-Line Mitopure Urolithin A, 10% off Code MODERN https://timeline.sjv.io/k4JrNx *AX3 Life* (20% off: MODERN20) https://ax3.life/MODERN20 - Astaxanthin *Viome* Full Body Intelligence https://viomehq.sjv.io/X4rkBg *n1o1* (10% off: Modern) https://tidd.ly/3IczGRW - Nitric Oxide Lozenges *Qualia* (15% off: MODERN) Creatine+ https://tinyurl.com/mr3z35jd Senolytic https://bit.ly/4jlaibe *Qitone* (10% off: HEALTH10) https://tidd.ly/4jGklry Qitone Esters Powder *MitoQ* https://tinyurl.com/5n93fm3f MitoQ Pure https://tinyurl.com/3hxy9s7x *Wellness Extract* (10% off: MODERNWE) http://wellnessextract.com/RICHARDWE Geranylgeraniol • Vit E *Oxford Healthspan* (15% off: MHS) https://tinyurl.com/hrxfnzpn - Spermidine *ProHealth* (15% off: MODERN) https://prohealth.pxf.io/aObQRR NMNH 500mg ~~~~~~~~~~~~~~ For decades, the slow chemical bonding of sugars to long-lived structural proteins, a process called glycation, was considered a permanent, one-way street in biogerontology. Advanced glycation end products (AGEs) like Nε-carboxymethyl-lysine (CML) accumulate over a lifetime in arteries, skin, and eye lenses, triggering chronic NF-κB inflammation and cellular decay via RAGE receptors. In a breakthrough proof-of-concept study, scientists engineered CMLase, a bacterial enzyme capable of performing oxidative deglycation. Ex vivo tests on human donor tissue revealed that CMLase stripped away over 70% of CML burden in 75-year-old abdominal arteries and over 55% in 75-year-old skin, dropping chemical damage markers below 31-year-old baseline levels. This video breaks down the enzymatic mechanism of CMLase, the crucial distinction between protein adducts and structural cross-links like glucosepane, actionable lifestyle strategies to inhibit endogenous glycation today, and the commercial landscape surrounding this biotech milestone. 📚 Chapters 00:00 - The Science of Protein Glycation & Aging 01:56 - How Engineered CMLase Degrades AGEs 03:52 - Reversing Glycation in Aged Human Tissue 05:44 - 3 Practical Strategies to Reduce AGEs Today 07:48 - Cross-Linking Realities & Translation Challenges 🌐Scientific Reference Study Title: Enzymatic cleavage of Nε-carboxymethyl-lysine resets protein glycation burden in human tissues (Development and ex vivo validation of CMLase). Research Entities: Revel Pharmaceuticals, Calico Life Sciences, and University of Colorado Anschutz Medical Campus. Link: https://www.nature.com/articles/s41467-026-75141-2 *************************************** Disclaimer: This content is for educational and informational purposes only and covers early-stage laboratory and ex vivo research published by researchers affiliated with Revel Pharmaceuticals, Calico Life Sciences, and the University of Colorado Anschutz Medical Campus. CMLase is an experimental proof-of-concept enzyme and is not available for human clinical or therapeutic use. This video does not constitute medical advice, diagnosis, or treatment recommendations. Always consult a qualified physician or healthcare professional before making changes to your diet, lifestyle, or medical protocols. ********************************************** #longevity #CMLase #antiaging