NEW... Ranking of Scientific Articles in Anti-Ageing (1996-2025)

This analytical report provides a systematic ranking and high-fidelity longitudinal evaluation of scholarly publications across the global Anti-Aging and Geroscience landscape from 1996 to the end of 2025. Spanning three decades of radical paradigm shifts—from the initial discovery of longevity genes in simple organisms to the 2025 era of systemic epigenetic rejuvenation and AI-designed senolytics—this analysis identifies the "citation classics" that have fundamentally redefined aging not as an inevitable decline, but as a plastic and potentially reversible biological process. The ranking is established using a robust, multi-dimensional bibliometric framework. Beyond raw citation counts, the methodology incorporates Field-Weighted Citation Impact (FWCI), Hallmark Integration Velocity (alignment with the "Hallmarks of Aging" framework), and Clinical Translation Index (progression into Phase II/III human longevity trials). The report categorizes the evolution of anti-aging research through three pivotal eras: The Genetic & Metabolic Foundation Era (1996–2005): Focus on the formalization of Sirtuin biology (Sinclair, Guarente et al.), the discovery of the first longevity genes in C. elegans, and foundational research on Caloric Restriction (CR) and its impact on the insulin/IGF-1 signaling pathway. The Hallmarks & Senolytic Revolution (2006–2015): The era of the "Hallmarks of Aging" (López-Otín et al., 2013), dominated by the breakthrough of Cellular Reprogramming (Yamanaka factors, 2006/2012) and the first identification of Senolytics (Kirschland et al.)—drugs designed to selectively eliminate "zombie" senescent cells. The Epigenetic Clock & Reversal Era (2016–2025): The dominance of Epigenetic Clocks (Horvath/Morgan Levine) for measuring biological age, the bibliometric surge in Partial Reprogramming for whole-organ rejuvenation (Altos Labs era), and the 2025 breakthroughs in AI-orchestrated personalized longevity interventions and lysosomal restoration. By tracking these metrics through 2025, the study documents the historic shift from palliative geriatric care to preventative, regenerative, and longevity-focused molecular medicine. This compilation serves as the premier strategic resource for gerontologists, biotech investors, and academic researchers to identify the cornerstone publications that continue to define the future of human healthspan in the 21st century.