Is Rapamycin Safe? The Truth Behind the Longevity Trend

Rapamycin has become one of the most talked-about longevity drugs, but how much do we actually know? In this clip, Dr. Ted Lain and Dr. Patti Farris break down how rapamycin works on the mTOR pathway to boost autophagy and mitochondrial function, plus what the limited human data actually shows — including a survey of 200–300 off-label users that found no major safety red flags, aside from oral ulcers in about 15% of patients (which some believe may signal a therapeutic dose). Ted and Patti also dig into a 52-week trial that was undermined by a compounding error — the "10mg dose" turned out to have the bioavailability of just 3mg — and why that means the real answer on optimal rapamycin dosing and benefits is still TBD. Spoiler: safety looks promising so far, but rigorous, unrestrained human trials haven't caught up to the hype yet. 🎧 Full episode of The Science of Skin Podcast available now 🍎 Apple Podcasts — https://podcasts.apple.com/us/podcast/skincare-confidential/id1664286292 🎵 Spotify — https://open.spotify.com/show/49NtbRxb32CJu2XtSV6tso 📦 Amazon Music — https://music.amazon.com/podcasts/7de48e5e-f450-466b-a0f4-f2275b67757f/skincare-confidential 💚 iHeart Radio — https://www.iheart.com/podcast/269-the-science-of-skin-269540115/ 📻 Audacy — https://www.audacy.com/podcast/skincare-confidential-4398f Disclaimer: This clip is not intended to provide diagnosis, treatment, or medical advice. Content provided in this podcast is for educational purposes only. Please consult with a physician regarding any health-related diagnosis or treatment. #Rapamycin #Longevity #mTOR