Immunologist Alan Landay discusses inflammaging and immune aging in a video conversation
In this Decoding Longevity episode description, Raghav Sehgal and Macsue Jacques talk with immunologist Alan Landay about how chronic immune activation, gut microbiome disruption and systemic inflammation are described as contributing to accelerated aging, with insights said to come from HIV research and to apply broadly. [1]
Automatic summary · not editorially reviewed
The key findings
The description presents Alan Landay as an immunologist drawing on more than four decades of research. [1]
The description says chronic immune activation, gut microbiome disruption and systemic inflammation contribute to accelerated aging. [1]
The description says the insights emerged from HIV research but apply broadly to the general population. [1]
The source at a glance
- Study type / format
- Video description of an expert conversation (episode of Decoding Longevity)
- Population / context
- General population, with insights said to come from HIV research
- Summary based on
- Creator description
- Original publication
- February 18, 2026
Landay's four decades of immune aging research
The description presents Alan Landay as a renowned immunologist drawing on more than four decades of research. The conversation, hosted by Raghav Sehgal and Macsue Jacques, frames aging as possibly driven less by time and more by the state of the immune system. The episode is described as exploring the hidden biology of aging through inflammation and immune function.
Supporting source [1]
Inflammaging, gut–immune link and aging clocks
According to the description, Landay explains how chronic immune activation, gut microbiome disruption and systemic inflammation contribute to accelerated aging. The episode promises to cover what inflammaging means, how the gut–immune connection shapes biological age, why immune cells can drive tissue decline across organs, the science behind biological aging clocks, and emerging therapies targeting inflammation and healthspan. These are topics the description says are covered, not results reported in it.
Supporting source [1]
HIV research origins and a systems-level view
The description says the insights emerged from HIV research but apply broadly to the general population. It calls the episode a systems-level view of aging in which immunity, metabolism and environment converge to shape how we age. The description does not report study designs, sample sizes, measured outcomes or effect sizes, so no specific finding can be checked from it.
Supporting source [1]
How to interpret this
This explainer is based only on the video description. The video and transcript were not reviewed, so the described topics, the HIV-research origin and the claimed broad applicability cannot be verified here. The description reports no study design, sample, follow-up or measured outcomes, and statements about contributing to aging are associations described by the creator, not proven causes.
Based on the creator’s description; the full video and transcript were not analyzed.
Source & supporting passages
Decoding Longevity · youtube.com · February 18, 2026