Review: multiscale bone aging and proposed rejuvenation strategies
This review describes bone aging as a networked decline across molecular, cellular, tissue and system levels, and lists non-drug, drug and emerging strategies; it reports no new experiments or outcomes. [1]
Automatic summary · not editorially reviewed
The key findings
The review describes bone aging as a multi-level, networked degenerative phenomenon across molecular, cellular, tissue and system levels, not merely bone mass loss. [1]
Listed interventions include dietary optimization, physical activity, avoidance of alcohol and tobacco, antiresorptive agents, anabolic bone-forming drugs and senolytics. [1]
Future directions proposed include a multi-omics-integrated bone aging atlas, bone organoids, computational models and precision therapies targeting aging-related pathways. [1]
The source at a glance
- Study type / format
- Narrative review (abstract only)
- Population / context
- Bone aging and bone degenerative diseases in the context of global population aging
- Summary based on
- Study abstract
- Original publication
- September 14, 2026
Bone aging framed as multilevel decline
The review states that bone aging is not merely bone mass loss but a multi-level, networked degenerative phenomenon spanning molecular, cellular, tissue and system levels. At the macroscopic level it describes declines in bone mass, microstructure and biomechanical properties, leading to increased fragility. It links this to global population aging and calls bone degenerative diseases a major public health challenge.
Supporting source [1]
Listed mechanisms and proposed interventions
At the microscopic level the review lists molecular mechanisms such as genetic and epigenetic alterations, oxidative stress, the senescence-associated secretory phenotype and dysregulated signaling pathways. Cellular changes include telomere attrition, mitochondrial and endoplasmic reticulum dysfunction, impaired proteostasis, altered nutrient sensing and cellular senescence. Microenvironmental and systemic factors include chronic inflammation, hormonal changes and extracellular matrix remodeling. As corresponding strategies it names dietary optimization, physical activity and avoidance of alcohol and tobacco, plus antiresorptive agents, anabolic bone-forming drugs and senolytics; regenerative medicine, gene therapy and tissue engineering are called emerging avenues.
Supporting source [1]
Proposed research agenda, not tested results
The review proposes future work: a multi-omics-integrated bone aging atlas, bone organoids and computational models, multimodal risk assessment systems, precision therapies targeting aging-related pathways and prevention-centered public health strategies. It presents itself as a framework for understanding bone aging and for guiding interdisciplinary collaboration, translational research and clinical interventions. No study design, sample, follow-up or measured outcome is reported in the abstract.
Supporting source [1]
How to interpret this
Abstract only; the full text was not reviewed. This is a review that synthesizes mechanisms and proposes strategies; the abstract reports no study design, sample, follow-up or measured outcomes, so the listed interventions are not shown here to work.
Based on the study abstract; the full paper, tables and supplementary data were not reviewed.
Source & supporting passages
Li K, Gao C, Zhang T, Wang C, Geng X, Wang X, Tian H. · europepmc.org · September 14, 2026