Muscle age acceleration and resting-state EEG connectivity in 101 older adults
In 101 healthy older adults, muscle age acceleration groups differed in resting-state EEG connectivity: the decelerated group showed lower coherence than normal and accelerated groups in several alpha and beta bands. The abstract reports associations only. [1]
Automatic summary · not editorially reviewed
The key findings
Eyes-closed resting-state EEG was recorded from 101 healthy, neurologically intact older adults. [1]
The decelerated muscle age group had significantly lower coherence than normal and accelerated groups in Alpha 1, Alpha 2 and Beta 1 bands. [1]
The authors say the findings may suggest that divergent muscle aging trajectories modulate brain network topography. [1]
The source at a glance
- Study type / format
- Abstract of an observational EEG study with cross-sectional group comparison
- Population / context
- 101 healthy, neurologically intact older adults
- Summary based on
- Study abstract
- Original publication
- September 2, 2026
EEG and muscle age in 101 older adults
The study recorded eyes-closed resting-state electroencephalography (EEG) from 101 healthy older adults described as neurologically intact. Muscle age and muscle age acceleration were quantified with a regression model using functional assessments recommended by the European Working Group on Sarcopenia in Older People (EWGSOP-2) consensus: anthropometrics, muscle strength and motor functional tests. Participants were divided into three groups by muscle age acceleration: decelerated, normal and accelerated.
Supporting source [1]
Lower coherence in the decelerated muscle age group
Brain connectivity was assessed with magnitude-squared coherence and node strength analyses. The decelerated muscle age group showed significantly lower coherence than the normal and accelerated groups in the Alpha 1, Alpha 2 and Beta 1 bands. In node strength, the decelerated group had lower values in the right frontal area across Alpha 1, Beta 1 and Beta 2 bands. The normal group had lower values in the right temporal region than the accelerated group.
Supporting source [1]
Abstract-only associations, not causal effects
The authors describe these findings as possibly suggesting that different muscle aging trajectories modulate brain network organization. This is an association in a cross-sectional comparison of groups, not evidence that muscle aging causes connectivity differences. The abstract does not report effect sizes, how groups were cut off, or whether other factors were adjusted for. Proposed personalized interventions to redirect muscle aging are framed as potential, not tested here.
Supporting source [1]
How to interpret this
Abstract only; the full text was not reviewed. The abstract reports group comparisons without effect sizes, group cutoffs or adjustment details, and the authors frame the link as a possible association.
Based on the study abstract; the full paper, tables and supplementary data were not reviewed.
Source & supporting passages
Frasca F, Pappalettera C, Cacciotti A, Ventura L, Morrone M, Manca A, Deriu F, Vecchio F. · europepmc.org · September 2, 2026