Acute treadmill exercise and adipose FAHFA lipokines in lean, obese and aged mice
In previously untrained male mice, acute treadmill exercise raised FAHFA levels in adipose tissue only in lean animals; this response was impaired in obese and aged mice, while plasma FAHFA changed little in all groups. [1]
Automatic summary · not editorially reviewed
The key findings
The source at a glance
- Study type / format
- Animal study (abstract)
- Population / context
- Previously untrained lean, obese and aged male C57BL/6J mice.
- Summary based on
- Study abstract
- Original publication
- July 25, 2026
Lean, obese and aged mice before and after acute exercise
The study compared previously untrained lean, obese and aged male C57BL/6J mice. All were subjected to acute treadmill exercise. Adipose tissue lipolysis, a metabolomic profile and FAHFA levels were analysed at baseline and at 0 and 3 hours after exercise. At baseline, adipose tissue FAHFA levels, particularly those containing mono- and polyunsaturated fatty acids, were lower in obese and aged mice than in lean mice.
Supporting source [1]
Exercise raised adipose FAHFA only in lean mice
In lean mice, acute exercise increased plasma non-esterified fatty acids and their release from adipose tissue explants; this was suppressed in obese and aged mice. Only in lean animals did acute exercise lead to a time-dependent increase in total FAHFA levels in adipose tissue, most pronounced in 13/12-regioisomers from different FAHFA subfamilies. This effect was stronger than that of fasting alone, with palmitoleic acid-containing FAHFA most differentiating. Plasma FAHFA levels were minimally affected in all groups.
Supporting source [1]
Abstract-only mouse findings on obesity and ageing
The authors conclude that acute exercise increases FAHFA levels in adipose tissue but not in plasma, and that this effect appears to be negatively affected by obesity and ageing. Adipose tissue expression of genes related to de novo lipogenesis and lipolysis was reduced, particularly in obese mice, while expression of FAHFA hydrolysis-related genes was higher in aged mice. These are associations in mice, not evidence of human lifespan or health benefits.
Supporting source [1]
How to interpret this
This is an abstract; the full text was not reviewed. Findings come from male C57BL/6J mice, not humans, and describe associations after acute exercise, not causes or lifespan effects.
Based on the study abstract; the full paper, tables and supplementary data were not reviewed.
Source & supporting passages
Mitrovic M, Horakova O, Riecan M, Kleinova V, Cajka T, Rossmeislova L, Kuda O, Rossmeisl M. · europepmc.org · July 25, 2026