Review of targeted strategies to eliminate senescent cells in age-related disease
This review describes immunotherapy, engineered extracellular vesicles and nano-based drug delivery as approaches to remove senescent cells more precisely, because current senolytics lack selectivity and may cause off-target toxicity. [1]
Automatic summary · not editorially reviewed
The key findings
Senescent cells accumulate with age and are described as contributing to age-related diseases such as neurodegeneration and cardiovascular disorders. [1]
Current senolytics lack precise selectivity and may cause off-target toxicity, motivating more precise interventions. [1]
The review summarizes immunotherapy, engineered extracellular vesicles and nano-based drug delivery for targeted senescent-cell elimination. [1]
The source at a glance
- Study type / format
- Narrative review (abstract)
- Population / context
- Senescent cells and age-related diseases in general; no human participants described.
- Summary based on
- Study abstract
- Original publication
- July 15, 2026
Senescent cells and limits of current senolytics
The review defines cellular senescence as a cell fate with a prolonged and generally irreversible stop of the cell cycle, triggered by stressors and certain physiological events. Senescent cells accumulate with age and are described as contributing to the pathogenesis of age-related diseases such as neurodegeneration and cardiovascular disorders. Removing them is presented as a promising therapeutic approach, which led to senolytic agents. However, the authors state that current senolytics lack precise selectivity and may cause off-target toxicity, so more precise interventions are needed.
Supporting source [1]
Three targeted elimination strategies summarized
The review summarizes recent progress in targeted elimination of senescent cells through immunotherapy, engineered extracellular vesicles and nano-based drug delivery systems. According to the significance statement, these strategies use and process biomaterials to achieve precise clearance of senescent cells. The authors also say they explain the molecular mechanisms of action and discuss challenges and prospects, aiming to offer insights for improving biomaterials and therapeutic strategies.
Supporting source [1]
Potential applications and stated limitations
The review introduces potential applications of these targeted strategies across various age-related diseases. It then discusses limitations and future development directions at length. The abstract frames the global aging population and the threat of age-related diseases to health and socioeconomic systems as context. It reports no experiments, participants, outcomes or effect sizes; the described strategies are presented as a research overview, not as established treatments.
Supporting source [1]
How to interpret this
Abstract only; the full text was not reviewed. No study design, sample, follow-up, outcome data or effect sizes are reported, and the strategies are described as a research overview rather than established treatments.
Based on the study abstract; the full paper, tables and supplementary data were not reviewed.
Source & supporting passages
Chen Y, Zhu D, Xu W, Miao X, Jiang Z. · europepmc.org · July 15, 2026