Lab study: hydrolyzed yeast protein extract and SIRT6 in three human skin cell types
In laboratory (in vitro) experiments, a proprietary hydrolyzed yeast protein extract increased SIRT6 measures in skin cells, reduced UVB-related inflammation and DNA damage in keratinocytes, slowed telomere attrition in aged fibroblasts and lowered melanin in a 3D model. These are cell-level findings, not evidence of visible skin benefits in people. [1]
Automatic summary · not editorially reviewed
The key findings
A proprietary hydrolyzed yeast protein extract, described as a SIRT6 activator, was tested in a series of in vitro studies on three human skin cell types. [1]
HYPE increased SIRT6 protein expression in keratinocytes and SIRT6 gene expression in dermal fibroblasts. [1]
In aged dermal fibroblasts HYPE decreased the rate of telomere attrition, and in melanocytes in a 3D skin model it reduced melanin content. [1]
The source at a glance
- Study type / format
- Series of in vitro laboratory studies (abstract)
- Population / context
- Normal human epidermal keratinocytes, dermal fibroblasts and melanocytes (the latter in a 3D skin model); no human participants.
- Summary based on
- Study abstract
- Original publication
- October 12, 2026
SIRT6 activator tested in three skin cell types
The abstract describes a series of in vitro studies on a proprietary Hydrolyzed Yeast Protein Extract (HYPE), described as a SIRT6 activator. SIRT6 is called a master epigenetic regulator of cellular functioning and homeostasis in skin. The authors frame the work around photoaging and chronological age-related changes such as telomere attrition, which they say can lead to accumulation of senescent skin cells. The extract was tested in normal human epidermal keratinocytes (NHEK), dermal fibroblasts and melanocytes, the last in a 3D skin model.
Supporting source [1]
Measured effects after UVB, in aged fibroblasts and melanocytes
Treatment with HYPE increased SIRT6 protein expression in NHEK and SIRT6 gene expression in dermal fibroblasts. In keratinocytes it attenuated NF-κB-mediated inflammation after UVB exposure and protected them from DNA damage after UVB irradiation. In aged dermal fibroblasts it decreased the rate of telomere attrition. In melanocytes in a 3D skin model it reduced melanin content. These are measured laboratory outcomes; the abstract does not report effects on visible skin aging in people.
Supporting source [1]
Authors propose skincare use; abstract reports no human data
The authors conclude that HYPE's activity across all three skin cell types makes it a potential agent for skincare formulations designed to reverse visible aging. This is a proposal, not a demonstrated product effect. The abstract reports only in vitro work, with no human participants, no clinical outcomes and no data on safety in use. It also gives no effect sizes or statistical details. Whether such cell-level changes translate into visible skin benefits remains untested here.
Supporting source [1]
How to interpret this
Abstract only; the full text was not reviewed. All reported work is in vitro, with no human participants, clinical outcomes, effect sizes or safety data. The skincare use is a proposal by the authors, not a demonstrated benefit.
Based on the study abstract; the full paper, tables and supplementary data were not reviewed.
Source & supporting passages
Dong K, Rella A, Goyarts EC, Trivero J, Pernodet N, Kala R. · europepmc.org · October 12, 2026