Bibliometric review maps anti-aging drug literature 2005–2025 and proposes prioritization framework
This bibliometric-guided, strategy-oriented review maps explicit anti-aging drug literature from 2005 to 2025, names historically influential compounds and proposes a framework for prioritizing candidate gerotherapeutics; it is a literature synthesis, not a clinical trial. [1]
Automatic summary · not editorially reviewed
The key findings
The review maps explicit anti-aging drug literature from 2005 to 2025 using a bibliometric-guided, strategy-oriented approach. [1]
The field is described as converging on three partially overlapping intervention axes, including senotherapeutics and nutrient-sensing gerotherapeutics. [1]
The Top 10 anchors are prioritized by bibliometric prominence rather than clinical ranking. [1]
The source at a glance
- Study type / format
- Bibliometric-guided, strategy-oriented literature review (abstract)
- Population / context
- Explicit anti-aging drug literature published from 2005 to 2025
- Summary based on
- Study abstract
- Original publication
- June 28, 2026
Review scope: anti-aging drug literature 2005–2025
The review describes a shift in anti-aging pharmacology from early exploratory lifespan-extension studies toward a hallmark-informed, multi-level framework combining mechanistic, preclinical and translational evidence. Using a bibliometric-guided, strategy-oriented approach, it maps the explicit anti-aging drug literature from 2005 to 2025 and identifies historically influential compounds.
Supporting source [1]
Three proposed intervention axes and Top 10 anchors
The field is said to converge on three partially overlapping intervention axes: senotherapeutics targeting cellular senescence and SASP signaling; nutrient-sensing and metabolic gerotherapeutics modulating mTOR, AMPK, autophagy and mitochondrial adaptation; and homeostasis-restoring agents reinforcing redox, inflammatory and circadian resilience. The Top 10 anchors are prioritized by bibliometric prominence rather than clinical ranking and are said to illustrate both potential and limitations in human translation.
Supporting source [1]
Framework aims to guide future gerotherapeutic prioritization
The synthesis presents itself as a structured framework for interpreting historical and contemporary literature, clarifying the relationship between multi-hallmark engagement and functional outcomes, and guiding rational prioritization of candidate gerotherapeutics for future research. Emerging candidates and platform innovations are mentioned as ongoing progress toward precision geromedicine. The abstract reports no primary data, sample, follow-up or outcome results.
Supporting source [1]
How to interpret this
Abstract only; the full text was not reviewed. This is a bibliometric-guided literature review, not a clinical trial, and the abstract reports no sample, follow-up, outcome data or effect sizes. The Top 10 anchors reflect bibliometric prominence, not clinical efficacy, and translational readiness is discussed as a framework proposal rather than validated human benefit.
Based on the study abstract; the full paper, tables and supplementary data were not reviewed.
Source & supporting passages
Liu Z, Abulaiti A, Li D, Li J, Wahafu P, Zhang Y, Maimaitiming M, Shu L, Li G, Yakufu M. · europepmc.org · June 28, 2026