Review: kinases linking autophagy and cellular senescence
This abstract describes a planned review of how protein kinases influence both autophagy and cellular senescence, two processes that can be triggered by similar stimuli and may affect each other. [1]
Automatic summary · not editorially reviewed
The key findings
The abstract says debates continue over whether autophagy and senescence are causally linked, whether autophagy promotes or prevents senescence, or whether they are independent. [1]
Mechanistic target of rapamycin complex 1 is called the master regulator of autophagy and is also said to influence senescence. [1]
The stated purpose is to learn from old and recent studies how kinases contribute to this field, with the aim of helping develop therapeutic strategies. [1]
The source at a glance
- Study type / format
- Review article (abstract only)
- Population / context
- Published studies on autophagy, cellular senescence and protein kinases, as discussed in a review
- Summary based on
- Study abstract
- Original publication
- June 28, 2026
Debated link between autophagy and senescence
The abstract notes that autophagy was first identified as a survival mechanism under nutrient deprivation or stress, while cellular senescence was seen as a tumor-suppressive mechanism. Both can be induced by similar stimuli and can influence each other. The text says debates continue over whether they are causally linked, whether autophagy promotes or prevents senescence, or whether they are independent.
Supporting source [1]
Kinases named as regulators of both processes
Protein kinases are described as central to cell fate decisions and as strongly influencing both autophagy and senescence. Mechanistic target of rapamycin complex 1 is called the master regulator of autophagy but is also said to influence senescence. Mitogen-activated protein kinases, originally associated with senescence, can regulate autophagy. The abstract states that a comprehensive review of how various kinases take part in this interplay is lacking.
Supporting source [1]
Stated aim: lessons for future therapies
The stated purpose is to draw lessons from older and recent studies to understand how kinases contribute to this changing field. The abstract says both autophagy and senescence can have beneficial and detrimental effects and that kinases are important drug targets. Insights into how kinases orchestrate these two processes should, according to the text, help develop therapeutic strategies for diseases such as aging and cancer. These are stated aims, not reported results.
Supporting source [1]
How to interpret this
This is an abstract only; the full text was not reviewed. The abstract describes the review's scope and aims but reports no studies, data, sample or outcomes. Statements about therapeutic strategies are stated goals, not demonstrated results.
Based on the study abstract; the full paper, tables and supplementary data were not reviewed.
Source & supporting passages
Basu A. · europepmc.org · June 28, 2026