Abstract: Epigenetic control of inflammaging in skeletal muscle and adipose tissue
This abstract describes how epigenetic regulation links metabolic stress to inflammation in ageing skeletal muscle and white adipose tissue, and how calorie restriction and exercise may partially reverse these effects. [1]
Automatic summary · not editorially reviewed
The key findings
Ageing is associated with reduced oxidative capacity, impaired mitochondrial turnover and anabolic resistance in skeletal muscle, and with adipocyte hypertrophy, hypoxia and immune cell infiltration in adipose tissue. [1]
Caloric restriction and physical exercise can partially reverse these effects by reprogramming the epigenome, according to the abstract. [1]
Both aerobic and resistance exercise are linked to epigenetic modifications associated with improved mitochondrial function, myogenesis, adipocyte health and reduced inflammatory gene expression. [1]
The source at a glance
- Study type / format
- Abstract of a review-style conceptual overview
- Population / context
- Ageing skeletal muscle and white adipose tissue, described in general terms
- Summary based on
- Study abstract
- Original publication
- June 1, 2026
Ageing muscle and adipose tissue changes
The abstract states that ageing is associated with a progressive decline in cellular function and systemic homeostasis, particularly in skeletal muscle and white adipose tissue. In skeletal muscle, ageing is said to lead to reduced oxidative capacity, impaired mitochondrial turnover and anabolic resistance. In adipose tissue, adipocytes are described as showing hypertrophy, hypoxia and increased immune cell infiltration. Together, these changes are said to promote persistent activation of inflammatory pathways and to contribute to systemic insulin resistance.
Supporting source [1]
Epigenetic mechanisms and lifestyle interventions
Epigenetic regulation is described as linking metabolic stress to gene expression through DNA methylation, histone acetylation and hydroxymethylation, influencing chromatin accessibility in ageing-related genes. Lifestyle interventions, including caloric restriction and physical exercise, are said to partially reverse these effects by reprogramming the epigenome. Both aerobic and resistance exercise are reported to promote epigenetic modifications associated with improved mitochondrial function, enhanced myogenesis, better adipocyte health and reduced inflammatory gene expression.
Supporting source [1]
Dynamic process in an abstract only
The abstract concludes that inflammaging is a dynamic and modifiable process in which epigenetic plasticity connects metabolic dysfunction to chronic inflammation and enables interventions that preserve metabolic health during ageing. These statements are presented as a conceptual overview; the abstract reports no study design, sample, follow-up or measured outcomes, so the described associations should not be read as proven causal effects in humans.
Supporting source [1]
How to interpret this
This is an abstract only; the full text was not reviewed. The abstract reports no study design, sample size, follow-up or measured outcomes, and the described associations are not evidence of causal effects in humans.
Based on the study abstract; the full paper, tables and supplementary data were not reviewed.
Source & supporting passages
de Melo DG, Cruz Rodrigues VCD, Sá Pereira GJ, Costa Fernandes CJD, de Moura LP. · europepmc.org · June 1, 2026