Review of dietary polyphenols and epigenetic mechanisms for muscle health in aging
This review describes how dietary polyphenols such as resveratrol, quercetin, epigallocatechin gallate and curcumin may act on signaling pathways and epigenetic processes and may help preserve muscle mass and strength in older adults; it reports no results of its own. [1]
Automatic summary · not editorially reviewed
The key findings
The review focuses on dietary polyphenols such as resveratrol, quercetin, epigallocatechin gallate and curcumin and on molecular and epigenetic mechanisms in sarcopenia. [1]
According to the abstract, these compounds may modulate mTOR, NF-κB and AMPK signaling and influence DNA methylation, histone modifications and microRNA regulation. [1]
The abstract states that polyphenols may reduce oxidative stress and inflammaging, enhance mitochondrial function and contribute to preserving muscle mass and strength in older adults. [1]
The source at a glance
- Study type / format
- Review (abstract only)
- Population / context
- Older adults, in the context of sarcopenia and muscle health during aging
- Summary based on
- Study abstract
- Original publication
- January 6, 2026
Polyphenols and sarcopenia: pathways and epigenetics
The review examines dietary polyphenols, including resveratrol, quercetin, epigallocatechin gallate and curcumin, in relation to sarcopenia, the loss of muscle mass and strength with aging. It focuses on molecular and epigenetic mechanisms. According to the abstract, these compounds may modulate signaling pathways such as mTOR, NF-κB and AMPK and may influence DNA methylation, histone modifications and microRNA regulation.
Supporting source [1]
Possible effects on oxidative stress and muscle
Through these proposed actions, the abstract states, polyphenols may reduce oxidative stress and chronic low-grade inflammation, described as inflammaging, enhance mitochondrial function and contribute to preserving muscle mass and strength in older adults. These are described as possible effects, not demonstrated outcomes. The abstract mentions evidence from experimental and clinical studies on muscle health and on prevention or attenuation of sarcopenia but gives no numbers, sample sizes or results.
Supporting source [1]
Epigenetic biomarkers and exercise in geroscience
The review also addresses current challenges and future perspectives. It highlights the role of epigenetic biomarkers and a possible synergy with physical exercise as part of integrated geroscience strategies to optimize muscle health during aging. These are described as perspectives, not as validated approaches. The abstract does not report which studies were included, how they were designed or what they found.
Supporting source [1]
How to interpret this
This is an abstract only; the full text was not reviewed. The abstract reports no study designs, sample sizes, follow-up or results, and the described effects and strategies are presented as possible mechanisms and perspectives, not established outcomes.
Based on the study abstract; the full paper, tables and supplementary data were not reviewed.
Source & supporting passages
Guilherme Da Silva Rodrigues, Leonardo Santos Lopes da Silva, Andressa Crystine da Silva Sobrinho, Jonas Benjamim, Gabriela Ferreira Abud, Gabriela Ueta Ortiz, Ellen Cristini de Freitas, Carlos Roberto Bueno Júnior · doi.org · January 6, 2026