CALM-HIV protocol: combined training in people with HIV aged 50 and older in Brazil
This abstract describes a planned nonrandomized trial in Brazil testing 12 weeks of supervised combined aerobic and strength training versus a control group in people with HIV aged 50 and older, stratified by time since diagnosis and antiretroviral exposure. [1]
Automatic summary · not editorially reviewed
The key findings
The planned trial will include people with HIV aged 50 years and older, stratified by time since HIV diagnosis and antiretroviral exposure. [1]
Participants will be allocated to a 12-week supervised combined training program with three sessions per week or to a control group. [1]
The abstract states that findings are expected to clarify differential responses across clinical subgroups and inform personalized exercise prescriptions. [1]
The source at a glance
- Study type / format
- Abstract of a nonrandomized clinical trial protocol
- Population / context
- People with HIV aged 50 years and older in Brazil, stratified by time since HIV diagnosis and antiretroviral exposure.
- Summary based on
- Study abstract
- Original publication
- October 1, 2026
Planned trial in older people with HIV in Brazil
The abstract says antiretroviral therapy has raised life expectancy for people with HIV, but long infection and treatment exposure are linked to early-onset sarcopenia, frailty and metabolic dysfunction. The planned trial will include people with HIV aged 50 years and older, grouped by time since HIV diagnosis and antiretroviral exposure. Combined aerobic and strength training is described as possibly easing these complications, with responses possibly differing by clinical history.
Supporting source [1]
Twelve weeks of supervised training versus control
Participants will be allocated to a 12-week supervised combined training program with three sessions per week or to a control group. The abstract does not say how allocation is done. Outcomes listed are physical performance (strength, frailty, gait), body composition measured by dual-energy x-ray absorptiometry, biochemical markers (lipid profile, CD4/CD8 ratio, inflammatory biomarkers) and psychosocial measures (quality of life, anxiety, depression, cognitive function).
Supporting source [1]
Expected subgroup differences, not yet observed results
The abstract presents expectations, not findings: the results are expected to clarify whether responses differ across clinical subgroups and to inform personalized exercise prescriptions for aging people with HIV. No participant numbers, follow-up beyond the 12-week program, or results are reported. Because this is an abstract of a protocol, the full text was not reviewed, and no effect of training on any outcome can be concluded from it.
Supporting source [1]
How to interpret this
Abstract only; the full text was not reviewed. This is a protocol, so no results, participant numbers or follow-up beyond the planned 12-week program are reported, and allocation methods are not described.
Based on the study abstract; the full paper, tables and supplementary data were not reviewed.
Source & supporting passages
Correia IM, de Moraes CALC, Brilhadori J, Dos Anjos JRC, Gonçalves Gomide EB, Cordeiro JFC, Borges J, Lopes Machado DR, Dos Santos AP. · europepmc.org · October 1, 2026