Replicating Dr Katchers Results Latest Update | Nicolas & Nina Interview
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Nicolas Chernavsky is reproducing Harold Katcher's rat rejuvenation experiment. In the latest update he talks about the protocol, the timeline, and what the results could mean.
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In 2023, Harold Katcher published a paper in the Journal of Neuroscience reporting 67% epigenetic rejuvenation in old rats following injections of extracellular particles derived from young pig plasma. No other published study has achieved comparable results in a mammal. The experiment has not been independently reproduced.
Nicolas & Nina have established the Rejuvenation Science Institute in Brazil to run an open replication of Katcher's study, in collaboration with UNICAMP. The experiment begins in April 2025. Rats will receive injections of PEPS — pig extracellular particles from young animals — and be assessed across five months using grip strength tests, memory tests, ten blood markers, and epigenetic clocks run by Steve Horvath's Clock Foundation.
Nicolas walks through the full protocol, explains the key differences from the original study, and outlines when interim results will be available. Results will be published openly as they come in.
⏲️Chapters
0:00 Introduction — the most important unreplicated experiment in ageing science
1:05 What PEPS are and how they differ from standard exosome therapies
3:45 The full protocol: from pig plasma to rat injection
7:30 Why the experiment is starting two months earlier than planned
9:00 The rat groups: old treated, old control, and the young treated addition
11:50 The measurement approach: grip strength, memory, blood markers, epigenetics
15:20 Interim results timeline: what to expect month by month
19:30 The longevity extension phase: what happens if rejuvenation is confirmed
23:00 Horvath's epigenetic clock: why the foundation sends DNA to the US
27:15 Crowdfunding and collaboration: UNICAMP, Do Not Age, and Helis Foundation
33:00 Aging-by-signalling: why this experiment tests a fundamental theory of ageing
40:00 The embryo rejuvenation precedent — we know rejuvenation is biologically possible
46:30 Can we visit the lab? Nicolas's open invitation
50:00 Where to follow the results and donate
🌐Links in this video
Rejuvenation Science Institute - ICR: https://www.rejuvenescimento.org/
English version of the ICR homepage: https://www.rejuvenescimento.org/english
The subscription for the newsletter of the ICR can be done on the ICR homepage.
Reversal of biological age in multiple rat organs by young porcine plasma fraction
https://pubmed.ncbi.nlm.nih.gov/37875652/
Scientific article in BioRxiv about the experiment with rats:
Feasibility of intravenous injections of pig plasma extracellular particles into rats — an acute study
https://www.biorxiv.org/content/10.1101/2024.11.28.625646v1
Harold Katcher's email address: hkatcher@earthlink.net
Harold Katcher's LinkedIn: https://www.linkedin.com/in/harold-katcher-340aa78/
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#lifeextension #E5 #Drkatcher
Modern Healthspan · 59 min · Source published: 2026-02-17
Added to Harbor: 10/23/2026
Original on YouTube ↗Automatically categorized source. Creator statements are not an independent evidence review or personal medical guidance.