Inflammaging the Immune System and the Hidden Biology of Aging — A Conversation with Alan Landay PhD

What if aging is driven less by time — and more by the state of your immune system? In Episode 20 of Decoding Longevity, Raghav Sehgal and Macsue Jacques sit down with renowned immunologist Alan Landay to explore the hidden biology of aging through the lens of inflammation and immune function. Drawing on more than four decades of research, Dr. Landay explains how chronic immune activation, gut microbiome disruption, and systemic inflammation contribute to accelerated aging — insights that emerged from HIV research but apply broadly to the general population. 🔬 In this episode, you’ll learn: ✔ What “inflammaging” really means ✔ How the gut–immune connection shapes biological age ✔ Why immune cells can drive tissue decline across organs ✔ The science behind biological aging clocks ✔ Emerging therapies targeting inflammation and healthspan This episode offers a systems-level view of aging — where immunity, metabolism, and environment converge to shape how we age. Subscribe for more conversations at the frontier of longevity science.