NMN and Aging: What Human Trials Actually Show (Not Mouse Data)

Every longevity influencer says NMN "reverses aging" — but that claim comes from mice. Here's what the actual human trials measured, and the one result (does it extend lifespan?) that no trial has tested yet. SOURCES (all cited claims trace to these): 1. Mills KF, Yoshida S, Stein LR, et al. "Long-Term Administration of Nicotinamide Mononucleotide Mitigates Age-Associated Physiological Decline in Mice." Cell Metab. 2016;24(6):795-806. PMID: 28068222. (foundational animal data — mouse study, not human) https://pubmed.ncbi.nlm.nih.gov/28068222/ 2. Liao B, Zhao Y, Wang D, et al. "Nicotinamide mononucleotide supplementation enhances aerobic capacity in amateur runners: a randomized, double-blind study." J Int Soc Sports Nutr. 2021;18:54. PMID: 34238308. https://pubmed.ncbi.nlm.nih.gov/34238308/ 3. Igarashi M, et al. "Chronic nicotinamide mononucleotide supplementation elevates blood nicotinamide adenine dinucleotide levels and alters muscle function in healthy older men." NPJ Aging. 2022;8:5. PMID: 35927255. https://pubmed.ncbi.nlm.nih.gov/35927255/ 4. "Effects of Nicotinamide Mononucleotide on Glucose and Lipid Metabolism in Adults: A Systematic Review and Meta-analysis of Randomised Controlled Trials." Curr Diab Rep. 2024. PMID: 39531138. https://pubmed.ncbi.nlm.nih.gov/39531138/ This is not medical advice. BioSourced — Science You Can Check. Subscribe for the next deep dive.