Video description: muscle ageing, mitochondria, nerves, hormones and NAD supplements

https://www.dralexnewsletter.com/ Join the community by signing up to my daily newsletter! Practical health advice, straight to your inbox, every morning. Why can some people in their seventies still spring up from a low armchair while others the same age need both hands and a bit of a run up? A lot of the answer sits deep inside the muscle, in the mitochondria that power every movement and the nerve connections that tell each fibre when to fire, and both respond to strength training far more than you might expect. If you're thinking about muscle loss after 50, sarcopenia, falls, insulin resistance or simply staying independent for longer, this one is worth your time. In this video I take you inside an ageing muscle and look at what the research shows, from older adults who had trained for decades to people with no training history whose muscle genes shifted back towards a younger pattern after six months of resistance exercise. We also get into the fast nerve fibres that tend to disappear first and why a daily walk doesn't really reach them, the fat hidden inside muscle that can push blood sugar up for years before diabetes is ever mentioned, how much testosterone and oestrogen really explain, and whether NAD supplements like nicotinamide riboside and NMN are worth the money. In this video you'll learn: -What happens to mitochondria and NAD inside an ageing muscle -Why lifelong exercisers avoided around half of the usual age related gene changes -Whether it's too late to start strength training in your seventies or eighties -How losing fast nerve connections affects power, balance and falls -Why fat stored inside muscle can push up blood sugar and insulin -How much of muscle ageing really comes down to hormones -What the evidence says about NAD supplements like NR and NMN -A simple weekly routine and a 30 second chair test to track your strength Whether you want to stay steady on your feet, keep your blood sugar in check or get off the sofa without thinking twice at 80, all of this can start this week, whatever your age. TIMESTAMPS 00:00 – Introduction 02:27 – What's actually going wrong inside the muscle 06:19 – The people whose muscles didn't get the memo 07:18 – Is it too late to start? 09:49 – The wiring nobody talks about 13:26 – The fat you can't see 15:38 – Is this all just hormones? 16:51 – The supplement shortcut and why it doesn't work 19:54 – What I'd actually do REFERENCES Delayed molecular aging, preservation of energy metabolism and enhanced exercise response in exercise-trained human muscle https://pubmed.ncbi.nlm.nih.gov/42399371/ Healthy aging and muscle function are positively associated with NAD+ abundance in humans https://pubmed.ncbi.nlm.nih.gov/37118369/ Mitochondrial oxidative capacity and NAD+ biosynthesis are reduced in human sarcopenia across ethnicities https://pubmed.ncbi.nlm.nih.gov/31862890/ Senescent cells promote tissue NAD+ decline during ageing via the activation of CD38+ macrophages https://pubmed.ncbi.nlm.nih.gov/33199924/ Resistance exercise reverses aging in human skeletal muscle https://pubmed.ncbi.nlm.nih.gov/17520024/ Exercise training and nutritional supplementation for physical frailty in very elderly people https://pubmed.ncbi.nlm.nih.gov/8190152/ Mechanisms of sarcopenia: motor unit remodelling and muscle fibre type shifts with ageing https://pubmed.ncbi.nlm.nih.gov/29989170/ Daily steps and all-cause mortality: a meta-analysis of 15 international cohorts https://pubmed.ncbi.nlm.nih.gov/35247352/ Skeletal muscle lipid content and insulin resistance: evidence for a paradox in endurance-trained athletes https://pubmed.ncbi.nlm.nih.gov/11739435/ Nicotinamide Riboside Augments the Aged Human Skeletal Muscle NAD+ Metabolome and Induces Transcriptomic and Anti-inflammatory Signatures https://pubmed.ncbi.nlm.nih.gov/31412242/ Aerobic and resistance exercise training reverses age-dependent decline in NAD+ salvage capacity in human skeletal muscle https://pubmed.ncbi.nlm.nih.gov/31207144/ NAD+ precursor supplementation in human ageing: clinical evidence and challenges https://pubmed.ncbi.nlm.nih.gov/41083806/ Dietary protein distribution positively influences 24-h muscle protein synthesis in healthy adults https://pubmed.ncbi.nlm.nih.gov/24477298/ Progressive resistance strength training for improving physical function in older adults https://pubmed.ncbi.nlm.nih.gov/19588334/ Muscle-strengthening activities are associated with lower risk and mortality in major non-communicable diseases: a systematic review and meta-analysis of cohort studies https://pubmed.ncbi.nlm.nih.gov/35228201/ Sarcopenia: revised European consensus on definition and diagnosis https://pubmed.ncbi.nlm.nih.gov/30312372/ Disclaimer: This is not personal medical advice and does not override what your doctor says. #dralex #doctoralex #strengthtraining #healthyageing #sarcopenia #longevity