This years biggest breakthroughs in longevity (2024 edition) !!!

Every year I compile what I think were some important contributions to longevity research. Here is my list for 2024! Find me on Twitter - https://twitter.com/EleanorSheekey Support the channel through PayPal - https://paypal.me/sheekeyscience?country.x=GB&locale.x=en_GB through Patreon - https://www.patreon.com/TheSheekeyScienceShow TIMESTAMPS Intro - 00:00 Stem cells - 00:30 Skin - 04:30 Reproduction and fertility - 05:30 What is aging? - 07:45 Immune response - 10:00 Lifespan extension - 12:30 References Disagreement on foundational principles of biological aging, PNAS Nexus, Volume 3, Issue 12, December 2024, pgae499, https://doi.org/10.1093/pnasnexus/pgae499 Shen, X., Wang, C., Zhou, X. et al. Nonlinear dynamics of multi-omics profiles during human aging. Nat Aging 4, 1619–1634 (2024). https://doi.org/10.1038/s43587-024-00692-2 Widjaja, A.A., Lim, WW., Viswanathan, S. et al. Inhibition of IL-11 signalling extends mammalian healthspan and lifespan. Nature 632, 157–165 (2024). https://doi.org/10.1038/s41586-024-07701-9 Olshansky, S.J., Willcox, B.J., Demetrius, L. et al. Implausibility of radical life extension in humans in the twenty-first century. Nat Aging 4, 1635–1642 (2024). https://doi.org/10.1038/s43587-024-00702-3 Miller, R.A., Harrison, D.E., Cortopassi, G.A. et al. Lifespan effects in male UM-HET3 mice treated with sodium thiosulfate, 16-hydroxyestriol, and late-start canagliflozin. GeroScience 46, 4657–4670 (2024). https://doi.org/10.1007/s11357-024-01176-2 Qu, Q., Chen, Y., Wang, Y. et al. Lithocholic acid phenocopies anti-ageing effects of calorie restriction. Nature (2024). https://doi.org/10.1038/s41586-024-08329-5 Ross, J.B., Myers, L.M., Noh, J.J. et al. Depleting myeloid-biased haematopoietic stem cells rejuvenates aged immunity. Nature 628, 162–170 (2024). https://doi.org/10.1038/s41586-024-07238-x Wang, H., Huang, Z., Shen, X. et al. Rejuvenation of aged oocyte through exposure to young follicular microenvironment. Nat Aging 4, 1194–1210 (2024). https://doi.org/10.1038/s43587-024-00697-x Induced pluripotent stem-cell-derived corneal epithelium for transplant surgery: a single-arm, open-label, first-in-human interventional study in Japan Soma, Takeshi et al. The Lancet, Volume 404, Issue 10466, 1929 - 1939 https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(24)01764-1/fulltext Transplantation of chemically induced pluripotent stem-cell-derived islets under abdominal anterior rectus sheath in a type 1 diabetes patient https://doi.org/10.1016/j.cell.2024.09.004 The use of ectopic volar fibroblasts to modify skin identity - https://doi.org/10.1126/science.adi1650 IgG is an aging factor that drives adipose tissue fibrosis and metabolic decline - https://www.cell.com/cell-metabolism/abstract/S1550-4131(24)00015-9 Spatial transcriptomic landscape unveils immunoglobin-associated senescence as a hallmark of aging https://doi.org/10.1016/j.cell.2024.10.019 Please note that the information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Sheekey Science Show and guests assume no liability for the application of the information discussed. Icons in intro; "https://www.freepik.com/free-photos-vectors/background"Background vector created by freepik - www.freepik.com