Multiomics atlas of subcutaneous fat in long-lived people versus controls
In an abstract, an integrated multiomics atlas of subcutaneous adipose tissue from 140 long-lived individuals and 70 controls reports less fibrosis, attenuated senescence and inflammatory signaling, preserved vascular and adipogenic features, and reduced biological-age acceleration in the long-lived group. These are associations, not causes. [1]
Automatic summary · not editorially reviewed
The key findings
The abstract describes a multiomics atlas of subcutaneous adipose tissue from 140 long-lived individuals and 70 controls. [1]
Long-lived individuals showed reduced fibrosis, attenuated senescence and inflammatory signaling, and preserved vascular and adipogenic features. [1]
A transcriptome-based adipose biological-age signature showed reduced age acceleration in long-lived individuals. [1]
The source at a glance
- Study type / format
- Abstract of a multiomics observational comparison
- Population / context
- 140 long-lived individuals and 70 controls, subcutaneous adipose tissue
- Summary based on
- Study abstract
- Publication status
- Preprint · peer-review status not confirmed
- Original publication
- September 24, 2026
Fat tissue atlas: 140 long-lived vs 70 controls
The abstract describes an integrated multiomics atlas of subcutaneous adipose tissue built from 140 long-lived individuals and 70 controls. It combined histology, bulk RNA sequencing, single-nucleus RNA sequencing, spatial transcriptomics and single-cell assay for transposase-accessible chromatin sequencing (scATAC-seq), a method for measuring chromatin accessibility. The stated aim was to address poorly understood cellular and epigenetic mechanisms behind preserved adipose tissue function in extreme human longevity.
Supporting source [1]
Less fibrosis and senescence in long-lived fat tissue
The abstract reports a coordinated adipose phenotype in long-lived individuals: reduced fibrosis, attenuated senescence and inflammatory signaling, and preserved vascular and adipogenic features. Single-nucleus profiling identified distinct Adip_1 and Adip_2 adipocyte states and showed greater progression toward the metabolically active Adip_2 state in long-lived individuals, consistent with preserved adipogenic differentiation. Spatial transcriptomics revealed attenuated senescence-associated and inflammatory niches and reduced fibro-inflammatory remodeling in long-lived adipose tissue.
Supporting source [1]
Biological-age signature and chromatin landscape findings
The abstract states a transcriptome-based adipose biological-age signature showed reduced age acceleration in long-lived individuals, plus a longevity-associated molecular program enriched for genes including SIRT3, PRKAA1, PPARG, UCP1, SIRT1, NFE2L2, NOS3, GPX1, ADIPOQ, SOD2 and FOXO3. scATAC-seq revealed a distinct regulatory landscape: preferential accessibility of PPARG, CEBPA, SREBF1, NFE2L2, KLF4, FOXO1 and NRF1 motifs in long-lived individuals, versus increased accessibility of TP53, JUN, NFKB1, STAT3, EGR1, RELA and ATF3 inflammatory and stress-associated motifs in controls. The authors describe these as programs that may underlie resilience.
Supporting source [1]
How to interpret this
This is an abstract only; the full text was not reviewed. The abstract reports associations between longevity and adipose features, not causes, and gives no follow-up, effect sizes or confounder details. The biological-age signature is transcriptome-based, and the proposed molecular programs are described as possibly underlying resilience.
Based on the study abstract; the full paper, tables and supplementary data were not reviewed.
Source & supporting passages
Corteletti M, Wei W, Mancini G, Conti N, Junjie X, Grün DZ. · europepmc.org · September 24, 2026