Proposed multi-omics framework: exercise across aging molecular layers
This review proposes a multi-omics framework in which exercise acts as a coordinated stimulus remodeling age-associated molecular dysfunction across genomic, epigenomic, transcriptomic, proteomic and metabolomic layers, with cell- and tissue-specific adaptations. [1]
Automatic summary · not editorially reviewed
The key findings
The review proposes a multi-omic framework in which exercise is a coordinated stimulus remodeling age-associated molecular dysfunction across five omics layers. [1]
Exercise is reported as associated with attenuation of age-associated hypermethylation in promoter regions and with modulation of genes for oxidative stress defense and tissue regeneration. [1]
The review states its unique contribution is synthesizing evidence that adaptations are highly cell- and tissue-specific, involving immune cells, skeletal muscle satellite cells, endothelial cells, microglia and intestinal stem cells. [1]
The source at a glance
- Study type / format
- Review (abstract only)
- Population / context
- Aging biological systems and exercise, as discussed in a review
- Summary based on
- Study abstract
- Original publication
- September 21, 2026
Proposed framework for exercise and aging molecules
The review describes aging as progressive molecular dysregulation across interconnected systems, including epigenetic regulation, gene expression, protein homeostasis and metabolic function. It proposes a multi-omic framework in which exercise is a coordinated biological stimulus that can remodel age-associated molecular dysfunction across genomic, epigenomic, transcriptomic, proteomic and metabolomic layers. The authors state that the integrative molecular mechanisms behind exercise's systemic effects remain incompletely understood.
Supporting source [1]
Reported associations across omics layers
The review reports that exercise is associated with modulation of DNA methylation patterns linked to inflammation, oxidative stress and tissue regeneration, and with attenuation of age-associated hypermethylation in promoter regions. Transcriptomic studies are said to show more youthful expression patterns alongside attenuated inflammatory and senescence-related gene programs. Proteomic studies link training to mitochondrial metabolism, extracellular matrix remodeling and muscle contractile protein abundance, reducing proteostatic dysfunction. Metabolomic analyses are said to show improved metabolic flexibility and remodeled cellular energy networks. These are described associations, not proven causes.
Supporting source [1]
Cell- and tissue-specific adaptations claimed
The review's stated unique contribution is synthesizing emerging evidence that these adaptations are highly cell- and tissue-specific, involving immune cells, skeletal muscle satellite cells, endothelial cells, microglia and intestinal stem cells. Rather than isolated pathways, exercise may induce convergent adaptations across interconnected molecular systems. The authors suggest healthy aging is dynamically regulated and that age-associated molecular dysfunction retains some biological plasticity.
Supporting source [1]
How to interpret this
This is an abstract of a review; the full text was not reviewed. The abstract reports proposed framework and described associations, not causal proof, and gives no sample sizes, study designs or effect estimates.
Based on the study abstract; the full paper, tables and supplementary data were not reviewed.
Source & supporting passages
da Silva Rodrigues G, Sousa Neto IV, Kawamura T, Carolino RO, Pinto AP, Dos Santos JDM, Cintra DE, Ropelle ER, Pauli JR, de Freitas EC, Taki Y, Radak Z, Ramos da Silva AS. · europepmc.org · September 21, 2026