Scoping review of 435 biological-aging papers: markers, mechanisms and metrics
This scoping review analyzed 435 papers on biological aging published from 2011 through June 2023, 309 of them on non-methylation-based biomarkers, and describes changing use of molecular markers over time, new metrics, and consistent and discordant findings. [1]
Automatic summary · not editorially reviewed
The key findings
The source at a glance
- Study type / format
- Scoping review (abstract)
- Population / context
- 435 published papers on biological aging from 2011 through June 2023
- Summary based on
- Study abstract
- Original publication
- September 8, 2026
Biological aging defined apart from chronological age
The review frames biological aging as a rapidly growing research area that aims to characterize the rate of aging independently of a person's chronological age. The authors analyzed results from biological aging research across 435 papers published in a 12-year window from 2011 through June 2023.
Supporting source [1]
Non-methylation biomarkers dominate the 435 papers
Of the 435 papers, 309 focus on non-methylation-based biomarkers. The review reports changing patterns in how molecular markers of biological aging are used over time, alongside the development of novel metrics of biological aging.
Supporting source [1]
Consistent and discordant findings and measurement questions
The authors identify consistent and discordant research findings and point to areas of potential future research. These focus on questions of measurement with biomarker-based assessment and on other variables relevant to the study of biological age.
Supporting source [1]
How to interpret this
Abstract only; the full text was not reviewed. The abstract reports no study-level designs, samples, follow-up or effect sizes, and describes a scoping review of published papers rather than new primary data.
Based on the study abstract; the full paper, tables and supplementary data were not reviewed.
Source & supporting passages
Ziesel A, Reeves J, Mallidou A, Newton L, Rhodes RE, Zhang J, Paterson T, Jabbari H. · europepmc.org · September 8, 2026