How a Simple Daily Multivitamin Slows Your Biological Clock | Drs Howard Sesso & Li Sidong

Dr. Howard Sesso and Dr. Sidong Li discuss the landmark COSMOS trial results, revealing how a daily multivitamin measurably slows biological aging and improves epigenetic clock scores. Some links are affiliate links so we will earn a commission when they are used to purchase products. If you would like to support our channel please consider joining our Patreon https://patreon.com/ModernHealthspan ~~~~~~~~~~~~~~ *Qualia* (15% off: MODERN) Creatine+ https://tinyurl.com/mr3z35jd Senolytic https://bit.ly/4jlaibe *Renue By Science* (10% off: MHS) https://tinyurl.com/bdew4bfs NMN Powder • Lipo NR *BiOptimizers* (15% off: MHBIO) https://bit.ly/47VAa8f - Magnesium Breakthrough, Gluten Guardian *Seeking Health* (10% off: Richard10) https://crrnt.app/SEEK/-dm0MyrQ, Histamine Nutrients https://crrnt.app/SEEK/EpM7paAO *Stemregen* (15% off: MODERN) *US only* https://tinyurl.com/45z968yr *MitoQ* https://tinyurl.com/5n93fm3f MitoQ Pure https://tinyurl.com/3hxy9s7x *Wellness Extract* (10% off: MODERNWE) http://wellnessextract.com/RICHARDWE Geranylgeraniol • Vit E *n1o1* (10% off: Modern) https://tidd.ly/3IczGRW - Nitric Oxide Lozenges *AX3 Life* (20% off: MODERN20) https://tinyurl.com/2t3w26nw - Astaxanthin *Qitone* (10% off: HEALTH10) https://tidd.ly/4jGklry Qitone Esters Powder *Oxford Healthspan* (15% off: MHS) https://tinyurl.com/hrxfnzpn - Spermidine *ProHealth* (15% off: MODERN) https://prohealth.pxf.io/aObQRR NMNH 500mg These are affiliate links - using them supports the channel at no extra cost to you. ~~~~~~~~~~~~~~ Can a simple daily supplement actually move the needle on human longevity? In this episode, we sit down with Dr. Howard Sesso of Harvard Medical School and Dr. Sidong Li to dive into the epigenetic results of the COSMOS trial, one of the largest randomized clinical trials ever conducted. With over 21,000 participants, this study provides "gold-standard" evidence on how common interventions like multivitamins and cocoa extract impact the aging process. We explore the fascinating data showing that a daily multivitamin significantly slows biological aging, particularly as measured by advanced second-generation epigenetic clocks like GrimAge and PhenoAge. Dr. Sesso and Dr. Li explain why these effects were most profound in individuals with existing health risks and accelerated aging, effectively acting as a nutritional "insurance policy" to restore a more youthful biological trajectory. If you’ve ever wondered if your daily vitamin habit is backed by rigorous science, this deep dive into the COSMOS data provides the definitive clinical answer. 📚 Chapters 0:00 Introduction: The COSMOS Trial Breakthrough 1:34 Meet the Experts: Dr. Howard Sesso & Dr. Sidong Lee 4:15 Why Focus on Epigenetic Clocks for Supplementation? 7:22 Multivitamins vs. Cocoa Extract: The Study Design 10:48 First-Generation vs. Second-Generation Clocks Explained 15:13 Results: How Multivitamins Slowed Biological Aging 21:40 Who Benefits Most? Correcting Nutritional Gaps 28:55 The Cocoa Extract Findings: A Different Mechanism? 34:10 Does the Quality of the Multivitamin Matter? 41:25 Understanding the "DunedinPACE" Speed of Aging 48:15 Clinical Outcomes: Does Lower Bio-Age Mean Less Disease? 54:16 The Future of COSMOS: What’s Next for Longevity Research? 🌐Links in this video COSMOS Trial home page https://cosmostrial.org/ Effects of daily multivitamin–multimineral and cocoa extract supplementation on epigenetic aging clocks in the COSMOS randomized clinical trial https://www.nature.com/articles/s41591-026-04239-3 #EpigeneticAging #Multivitamins #BiologicalAge